Dr. Shoesmith earned her Bachelor of Science degree from the University of Winnipeg in 1996 and her MD from the University of Manitoba in 2000. She is the President-Elect of CALS (Canada ALS Reasearch Network). She completed her neurology residency at Western University in 2005. From 2005 to 2007, Dr. Shoesmith completed a neuromuscular clinical fellowship with a specific focus on treatment and care of ALS patients at Western University. Her fellowship was sponsored by the Muscular Dystrophy Association.

In 2007, Dr. Shoesmith joined Dr. Michael Strong in the London Motor Neuron Diseases Clinic, where she focuses on conducting clinical trials in ALS (amyotrophic lateral sclerosis / Lou Gehrig's disease). She also has a general neuromuscular clinic and an EMG clinic. In 2010, Dr. Shoesmith became the Motor Neuron Diseases Clinic Director. Dr. Shoesmith is actively involved in teaching of residents and medical students.  She is the neuromuscular education coordinator for residents and fellows.  She is also a co-director of the neurosciences curriculum for medical students at the Schulich School of Medicine & Dentistry.