My research program focuses on the use of imaging to study physiological processes in diseases. My lab has pioneered a method of using x-ray dye and CT scanning to measure blood flow in various tissues including the brain, tumors, and the heart. The method has found applications in stroke for selecting patients for thrombolytic treatment, in cancer for monitoring anti-angiogenesis therapy, and in heart attack for identifying patients who would benefit from revascularization. The software implementing the method has been licensed to GE Healthcare and is distributed worldwide for use with their CT scanners.